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Imaging and epigenetics

Do you have any experience in the in vivo imaging community of the in vivo Epigenetic imaging ?

Is there a specialized team working on this project ?

Do you know some tools already used?

Thank you for your help

Penarier's blog
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imaging epigenetic effects

administrator - 08/30/2010 - 04:30

Interesting concept. You may consider using a luciferase reporter construct sensitive to epigenetic modulation and gene silencing - reversible with a DNA methyltransferase inhibitor. Valuable references are:

Effects of epigenetic modulation on reporter gene expression: implications for stem cell imaging. Krishnan et al., 2006. FASEB
Real-time in vivo imaging of p16Ink4a reveals cross talk with p53. Yamakoshi et al., 2009. J Cell Biol.
Epigenetic silencing of CXCL12 increases the metastatic potential of mammary carcinoma cells. Wendt et al., 2008. Oncogene

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Imaging and epigenetics

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imaging epigenetic effects

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