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Accelerating Preclinical Imaging Workflow

Accelerating Preclinical Imaging Workflow

Improving Image Acquisition, Reconstruction, Visualization, and Analysis.

Santosh S. Arcot, Ph.D. 

The Inveon® family of imaging systems from Siemens encompasses PET, SPECT, and CT technologies.

GEN Apr 15 2009 (Vol. 29, No. 8)

In vivo Imaging and CCD cameras

Choosing an In Vivo Optical Imaging system entails the evaluation of scientific grade CCD cameras.

Important parameters to consider are cooling,intensification, quantum efficiency, spectrum, dynamic range, frame rate, resolution, etc.

Cooling to absolute - 90oC will allow for maximal sensitivity by maximal suppression of dark current. Essential for snesitivity of detection of bioluminescent signals.

Targeting of perfluorocarbon microbubbles to selective populations of circulating blood cells.

Perfluorocarbon microbubbles (MBs) are routinely used as in vivo ultrasound contrast reagent. In addition, there is great interest in the use of MBs for ultrasound-mediated delivery, for example, of drugs and genes. As MB size (1-10 mum) limits their distribution to the vasculature, we aimed to assess the efficiency of targeting MBs to circulating cells using antibodies. Our experiments showed that MBs efficiently bind to erythrocytes and B-lymphoma cells in blood.

In Vivo molecular Imaging: the inside job

In vivo molecular imaging: the inside job

Nathan Blow1

Topographic thinning lung "onion"

inviCRO, together with the University of New Mexico and the Lovelace Respiratory Research Institute have developed an imaging assay to assess the deposition of radiolabeled particles of varying properties in the respiratory tract of mice and rats. The image analysis team at inviCRO has developed an approach based on topographic thinning or "onion peeling" to quantify the distribution of the radiolabeled particles within the lungs.

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